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doi: 10.1016/j.cellsig.2016.02.010

Deep and superficial vein thrombosis, Ischaemic lower leg due to peripheral vascular disease, thromboembolism or thrombosed popliteal aneurysm Traumatic muscle and tendon injuries such as calf muscle tear and / or haematoma (gastrocnemius, soleus or plantaris most commonly) and Achilles rupture Infective causes such as cellulitis or abscess formation Soft tissue tumours Referred radicular / neuropathic pain (sciatica)

Regularly clean and disinfect work surfaces and equipment to reduce contamination risks

The combination of pemetrexed and cisplatin may extend life expectancy for patients