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Finally, the authors also reported an improvement in cardiac function caused by optogenetic efferent VNS in normal rats, that was related to a reduced myocardial expression of GRK2 (G proteincoupled receptor kinase 2) and of -arrestin 2, both involved in 1-adrenergic receptor desensitization and internalization

Furthermore, it seeks to emphasize the importance of a careful and safe approach to the use of this substance, highlighting the need for technical training and rigorous monitoring to ensure clinical efficacy and patient safety

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Brantley M.A., Osborn M.P., Sanders B.J., Rezaei K.A., Lu P., Li C., Milne G.L., Cai J., Sternberg P., Jr

For extended storage, follow an appropriate validated laboratory protocol