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8Cd and D show that protein nitration in old-age neurons was reduced by nicotinamide or EGCG or the combination in 3xTg-AD neurons (ANOVA treatment F(3,26) = 5.7, p = 0.003), but only nicotinamide and combination reduced the protein nitration in old age nTg neurons (ANOVA treatment F(3,15) = 3.8, p = 0.03)