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This is problematic, as treatments aiming to increase Hb levels by a few grams per deciliter are clearly more promising for the treatment of patients with thalassemia intermedia than for the treatment of transfusion-dependent patients

Resistance to conventional chemotherapy or radiotherapy frequently involves upregulation of antioxidant pathways (e.g., the NRF2 and System Xc -GSH-GPX4 axis), rendering such cells highly vulnerable to ferroptosis ( ICIs ) can synergistically activate anti-tumor immune responses by promoting the release of tumor antigens and damage-associated molecular patterns ( This review aims to systematically analyze the molecular mechanisms of ferroptosis (lipid peroxidation drive, collapse of antioxidant defenses, and regulation of iron/lipid metabolism), its crosstalk with other cell death pathways, and key regulatory networks (e.g., NRF2, p53, Hippo-YAP pathways)

Furthermore, intramuscular injections carry higher risks, require a longer and thicker needle (which goes against everything we've just discussed), and can be significantly more painful

IDPs and IDRs are structurally highly variable