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The excellent safety profile observed in Phase 1 studies, along with an ongoing Phase 2 study, supports further investigation of Linafexor as a promising therapeutic option for NASH

For chronic excitotoxicity, the neurons were exposed to L-glu or NMDA for 24 h and for acute excitotoxicity for 10 min

A recent study demonstrated that mutant KRAS elevates AIFM2 levels by activating MAPK and NFE2L2/NRF2 (NFE2 like BZIP transcription factor 2), thereby suppressing ferroptosis in pancreatic cancer cells [147]