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Environ Sci Pollut Res Int

2.4 Pathological repercussions of oxidative stress High levels of ROS have the potential to damage cellular components by mediating lipid peroxidation, apoptosis, DNA damage, mitochondrial dysfunction and protein oxidation

Ancient Greek, Persian, and Roman physicians documented using snow, ice, and cold water for treating injuries and diseases

When Wnt pathway activation occurs, Twa1 translocates to the nucleus, and its conserved CRA (CT11-RanBPM) domain is required for its interaction with -catenin, which promotes -catenin nuclear retention and increases Wnt/-catenin downstream target gene expression