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Over the years, disulfide-containing compounds (-SS-) have been extensively explored in the development of GSH-sensitive drug delivery systems (DDSs) [52]

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The antioxidant effects of vitamin C and curcumin have been investigated in suppressing PIPN with demonstrated benefits in the reduction of TNF and IL6 levels in the DRG of rats [23, 24]

As a biomarker in clinical practice, it has been suggested as a proxy to evaluate neuroinflammation ( Although CNS IDDs might differ in several aspects, as previously mentioned, the extensive role performed by glial cells in neuroinflammation is a convergence point among them