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This link was not seen in those with normal B12 levels ( Another study suggested that people with high folate and low vitamin B12 levels may be up to 3.5 times more likely to experience a loss of brain function than those with normal blood parameters ( However, keep in mind that more studies are needed before it can be said with certainty that supplementing with high amounts of folic acid could be detrimental to mental health

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The efflux transporters transport a wide range of lipophilic molecules, whereas nutrient transporters ensure the supply of specific nutrients across the BBB and help in the removal of waste products by their transport from CNS into the blood [6, 24]