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In a post-hoc single-cell RNA sequencing analysis, data from patients with RMC before and after nivolumab plus ipilimumab treatment indicated that immune checkpoint therapy (ICT) triggered an interferon- response that induced a myeloid mimicry program in tumor cells, regulated by the CEBPB / p300 axis and linked to proliferation and hyperprogression

Dhar D, Mohanty A

With the accumulation of ROS (oxygen free radicals such as superoxide anion radical and hydroxyl radical), the endogenous antioxidant defense system (i.e., superoxide dismutase, catalase, glutathione ascorbate) fails to counteract ROS generation, resulting in an increase in oxidative stress (28, 33)

It patrols the physical environment inside the mitochondria, absorbing the hits from free radicals