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ABCG2 Gene Variants Are Particularly Common and Are Frequently Functionally Significant It is clear that variants in ABCG2 on chromosome 4q are quite common, and functionally significant on a frequent basis ( Table 1 - 4 )

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Although preclinical studies demonstrate that PI3K, AKT and mTOR inhibitors can effectively suppress tumor growth and induce apoptosis (73,113), their clinical utility has been hampered by dose-limiting toxicities and the emergence of resistance mechanisms (73,113)