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Key transcriptional regulators Nuclear factor erythroid 2-related factor 2 (NRF2) acts as the 'master regulator' of the cellular response to oxidative stress

For example, the excessive activation of ferritinophagy, lipophagy, clock autophagy, and CMA can promote ferroptosis by degrading iron proteins, lipid droplets, circadian rhythm regulators, and GPX4, respectively (Honma et al., 2023

The mass effect of the hematoma significantly increases intracranial pressure, compressing surrounding brain tissue and neural tracts, potentially leading to brain herniation (Wilkinson et al., 2018)

But what happens to all of that extracellular glutathione