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Thus, in normal ageing, the decrease in GSH couples with an age-related increase in free Fe 2+ to multiply the likelihood of ferroptosis, leading to death when combined changes in iron and GSH reach a critical threshold ( Figure 7 )

IUBMB Life 71:430441

Postmortem examination of patients with purpura fulminans and IMD revealed meningococcal microcolonies associated with the endothelium of different vessels of the two barriers, such as the capillaries of the choroid plexuses, meningeal vessels, and brain parenchyma vessels (Mairey et al., 2006