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SKU: 24639378635
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Description

Dis Colon Rectum (2020) 63(7):91826

The amalgamation of hydroxychloroquine (HCQ), a clinically accessible autophagy inhibitor, with vorinostat (VOR), an HDAC inhibitor, demonstrated safety at a maximum tolerated dosage of HCQ 600 mg and VOR 400 mg, accompanied by manageable gastrointestinal and hematologic toxicities, modest clinical efficacy in renal cell carcinoma and colorectal cancer, and pharmacodynamic evidence of elevated CDKN1A and CTSD expression in tumor biopsies (169)