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10.1016/s0306-4522(97)00252-2 Neuroscience 41 FurutaA.RothsteinJ

Content of Warning Letters Generally, any direct-to-consumer messaging about drugs, including by compounders, must include material facts, be balanced, and not be false or misleading

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions

Treatment of 48 cases of restless legs syndrome with dermal needle therapy