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In brief, mouse electrocardiography was measured in females [Young ( n = 6), Old Con ( n = 8), and Old mAb ( n = 7)] and males [Young ( n = 5), Old Con ( n = 6), and Old mAb ( n = 5)], using a Visual Sonic Vevo2100 imaging system (FUJIFILM VisualSonics Inc, Toronto, ON)

In colitis, aberrant activation of the MAPK cascade amplifies the production of pro-inflammatory mediators and cytokines, fostering a state of sustained inflammation and tissue damage

It has been shown that triterpenoids and quinones are key active Rubia yunnanensis compounds against hyperlipidemia, which is one of the key pathological factors of CCH (Wang et al., 2007), alisol A (Wu et al., 2023), and corosolic acid (Zhang et al., 2024) are potential active compounds in RY-A with neuroprotective effects