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Furthermore, the cerebral blood flow is higher in the hypothalamus of healthy volunteers carrying the T2D risk gene variant rs2334499 than volunteers carrying wild-type allele, indicating that the rs2334499 variant is positively correlated with insulin resistance [175]

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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]