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Additionally, genetics can play a role

Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A: Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor 1/insulin signaling and caloric restriction

Therefore, the signaling pathway mediated by 3-HKA activation of metabolic glutamate receptor 4(mGluR4) that promotes the conversion of astrocytes to the neuroprotective A2 phenotype and ultimately induces angiogenesis, and the neuroprotective effects provided by KYNA through antagonizing NMDAR and exerting antioxidant effects, synergistically constitute a dual neurovascular protective mechanism

414 The pathogenesis of autoimmune diseases includes genetic factors, cross-antigens, abnormal immune regulation and autoantigens