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In contrast, the genetic aetiology of a specific syndrome can be due to mutations in different genes, as in the case of Leigh syndrome (LS), which can be caused by nDNA and mtDNA mutations in more than 100 genes overall [12]

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Recently, it has been also demonstrated that SAMe treatment of glioblastoma cells induces cell cycle arrest and apoptosis, together with downregulation of DNA repair mechanisms promoting mitotic catastrophe-induced death [221]