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Their symptoms and severity vary differently

Optic Nerve Atrophy: Administering cyanocobalamin to patients with Leber's disease or hereditary optic nerve atrophy should be done cautiously, as it may worsen the condition

Qin XY, Cheng Y, Yu LC (2010) Potential protection of curcumin against intracellular amyloid -induced toxicity in cultured rat prefrontal cortical neurons