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HGF decreases cells sensitivity to chemotherapy through reducing apoptosis Exogenous HGF [39, 44,45,46,47,48] or endogenous HGF present in the conditioned media of cancer associated fibroblasts (CAFs) [38], has been shown to protect breast, glioblastoma, lung, ovarian cancer and osteosarcoma cells against apoptosis induced by the DNA damaging agents doxorubicin, cisplatin, camptothecin or paclitaxel

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