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doi: 10.1038/s41586-022-04569-5 181 SweetmanEKleffmannTEdgarCde LangeMVallingsRTateW

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PD-1 and anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are the most studied immune checkpoints, both of which are expressed on the surface of T cells and when activated by binding with their ligands, inhibit the activity of T cells (257)