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JCI Insight 9 , e169738 (2024)

Lysionotin promotes Nrf2 nuclear translocation and its downstream expression of antioxidant genes NQO-1 and HO-1 by phosphorylated activation of AMPK, thereby decreasing the intracellular ROS content and inhibiting TGF--induced myofibroblast differentiation

Some experimental models indicate that GHK-Cu may regulate fibrosis-related gene pathways, suggesting a possible role in conditions involving abnormal tissue scarring