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& Crepaldi, T

In our study, the ACTH levels might have possibly increased more gradually after the activation of the HPA-axis in response to the psychological stressor, and this might have resulted in a delayed feedback and therefore a longer cortisol response compared to physiological validation studies

They share the IGF-1 lineage but differ in origin, structure, receptor engagement, and duration of action, and they are not interchangeable in research