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5 Ferroptosis contributes to the diagnosis and treatment of PCOS Follicular development is a complex biological process of continuous change involving multiple hormones and regulatory factors, and the loss of oocytes from the ovary is irreversible (162)

It is well documented that the processes of cryopreservation and transplantation induce significant oxidative stress in ovarian tissue, a phenomenon closely paralleling the impact of ROS observed in cryopreserved oocytes (69, 70)

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