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Most available studies are limited by small sample sizes, short durations, and variability in study design, and importantly, they often include additional components alongside the three agents

Single standard substance for the simultaneous determination of eleven components in the extract of paeoniae Radix Alba (Root of Paeonia lactiflora Pall.)

Furthermore, the combined treatment reduced -catenin nuclear localization, cyclin D1 expression, and cellular proliferation (55)

IV administration overcomes this hurdle, enabling the body to achieve significantly higher, pharmacologic concentrations that cannot be reached orally