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doi: 10.1016/j.heliyon.2024.e38165, 95

This speculation is consistent with a recent report illustrating that precursor autoprocessing is context-dependent and its outcomes can be modulated by sequences outside the PR coding region 34

Most recently another controlled trial of prasinezumab (PADOVA), which had enrolled subjects with more advanced disease compared to the initial trial and randomised subjects to 4-weekly iv injections of 1500 mg prasinezumab or placebo for at least 76 weeks, used time to 5-point worsening on MDS-UPDRS part III scores as primary outcome measure

Moreover, the observed markers (MDA, SOD, GPX4 mRNA) are not exclusive to ferroptosis