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AIFM2 Apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also known as FSP1), a traditional apoptosis inducer in mitochondria, has recently been identified as an antioxidant regulator in ferroptosis, regardless of its mitochondrial function

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Article highlights Progressive familial intrahepatic cholestasis (PFIC) are rare, known paediatric-onset disorders of BA secretion and transport whose diagnosis is based on clinical symptoms to be confirmed with genetic tests that often reveal homozygosity or compound heterozygosity