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Cytochrome p450 oxidoreductase (POR) affects iron metabolism by removing hydrogen from polyunsaturated fatty acids, or by reducing Fe 3+ to Fe 2+ for electron transfer, to accelerate the circulation between Fe 3+ and Fe 2+ to promote ferroptosis (Zou et al., 2021)

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Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion