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In particular, the impact of sudden sedentarism caused by home confinement and travel restrictions on the population's physical, biochemical, and mentalemotional health and fitness can lead to measurable impairment occurring in just a few days, sufficient to induce neuromuscular dysfunction, insulin resistance, lowered aerobic capacity, increased respiratory exchange ratio and fat deposition, and cause low-grade systemic inflammation (29)

Insulin also stimulates lipid synthesis and storage by activating the same pathway and downstream targets such as SREBPs, ACC, and FAS (208)

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