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For example, the modification (s) in an FX polypeptide are in FXa having a light chain having an amino acid sequence corresponding to amino acid residues 1-139 of SEQ ID NO: 134 and a chain heavy that has an amino acid sequence corresponding to amino acids 195-448 of SEQ ID NO: 134 or one of its variants having catalytic activity and having at least 65%, 70%, 75%, 80%, 85 %, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more of sequence identity with an FXa having a light chain having a sequence of amino acids corresponding to amino acid residues 1-139 of SEQ ID NO: 134 and a heavy chain having an amino acid sequence corresponding to amino acids 195-448 of SEQ ID NO: 134, or to a catalytically active moiety of the same

10.3389/fnins.2025.1478304 42 BiesselsG

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