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The FDA has classified BPC-157 in Category 2 for bulk drug substances, citing possible safety issues in compounding, such as immunogenicity, impurities, and insufficient safety evidence for suggested administration routes

In clinical practice, even straightforward injectable treatments benefit from sterile technique, proper patient evaluation, and staff trained to recognize and manage adverse reactions

For seasonal allergies, some researchers begin KPV protocols 2 to 4 weeks before allergy season starts, aiming to stabilize mast cells before peak pollen exposure