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Complex-driven H 2 O 2 production was measured using Amplex Red (Thermo Fisher), according to the manufacturers instructions but with the following modifications: after 24 h of BPM31510 treatment, the media were aspirated and the cells were washed with 1 MAS buffer

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Disclosures: Roi Isaac: Cymabay therapeutics: Consultant, Jinyue Wang: Nothing to Disclose, Sion Kang: Nothing to Disclose, Victoria Nguyen: Nothing to Disclose, Charles McWherter: Nothing to Disclose, Jerrold Olefsky: Nothing to Disclose 1994 ANTI-FIBROTIC MICRORNAS ENRICHED IN EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STEM CELLS SUPPRESS FIBROGENESIS OF HEPATIC STELLATE CELLS BY DOWNREGULATION OF RHOA SIGNALING Daiki Kawamoto 1 Toshihiko Matsumoto 2 Tsuyoshi Fujioka 2 Naoki Yamamoto 1 Taro Takami 1 , 1 Yamaguchi University Graduate School of Medicine, 2 Yamaguchi University Graduate School Background: We have been developing a liver regeneration therapy for decompensated liver cirrhosis (DLC) using cultured autologous bone marrow mesenchymal stem cells (BMSCs)

For instance, Lactobacillus paracasei promotes lipid storage in intestinal cells, while Escherichia coli enhances lipid catabolism and ultimately inhibits lipid secretion [63]