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Interestingly, NMN could be cleaved in the extracellular milieu by the ecto-enzyme CD73 to produce NR, which in turn, can enter the cells and eventually support intracellular NAD + formation [31,32]

Vitamin B12 is naturally found in animal products like meat, fish, and dairy

Dietary requirements The daily requirement of vitamin B 12 has been set at 2.4 g, but higher amounts 4 to 7 g per day which are common in persons who eat meat or take a daily multivitamin, are associated with lower methylmalonic acid values

The average diet supplies about 5 to 15 mcg/day of Vitamin B12 in a protein-bound form that is available for absorption after normal digestion