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Using a genetically encoded fluorescent indicator, we find that cytosolic, but not mitochondrial, NADPH level increases during EC senescence

In support of this observation, there is heightened iNOS expression in multiple animal models of PD using 6-OHDA 23 , MPTP 24 , and even aSyn oligomers 25 whereas mice lacking iNOS are resistant to many PD-inducing stressors 26

Aging alters functionally human dermal papillary fibroblasts but not reticular fibroblasts: A new view of skin morphogenesis and aging