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J Immunol (2008) 181:74207

(2024) MMWR Morb Mortal Wkly Rep, 73: 708

For example, vitamin K antagonists (VKAs) indirectly impair coagulation by inhibiting VK-dependent coagulation factor synthesis, an effect which has slow onset and offset of action and has little correlation with drug concentration, making a PK assay of little value23