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In addition to immunomodulatory biomaterials, it is well known that MSCs of different tissue origins can potently promote pro-regenerative (M2) macrophage polarization while inhibiting pro-inflammatory (M1) macrophage activation both in vitro and in various preclinical disease models [14]

Nevertheless, most first-line drugs for the treatment of those disorders target the serotonin and/or dopamine systems either directly (e.g., in depression) or indirectly via modulation of GABA-A receptors

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However, if it has been more than 4 days since your last dose, then skip the missed dose and continue your regular dosing schedule