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Moreover, stretch influences oxidative stress responses and tissue remodeling, as regions of the lung exposed to abnormal mechanical forces become more susceptible to cigarette smoke-induced injury

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Fas (Apo-1/ CD95) is a 45-KDa surface receptor belonging to the nerve growth factor superfamily, which on binding by Fas ligand (FasL) induces translocation of phosphatidylserine from the inner to the outer leaflet of the cellular membrane and directly transduces the signal for programmed cell death