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Conclusion Compared to those taking GLP1-RAs, patients receiving SGLT2is had a lower risk of proliferative DR and vitreoretinal interventions, although the rate of any DR was comparable between the SGLT2i and GLP1-RA groups

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They reported that both VFT regions undergo ligand dependent conformational changes and intersubunit interactions between ECDs that further stabilize heterodimer formation for subsequent downstream signaling (Perez-Aguilar et al., 2019)