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In early Alzheimers disease (AD), excessive glycolysis leads to intracellular lactate accumulation, triggering excessive histone lactylation, amplifying glycolysis-related gene expression, and creating a feedback loop that exacerbates glucose metabolism in microglia [130]

4b) but cannot be used for enzymatic production (Supplementary Fig

Mature DCs then migrate to lymph nodes, where they effectively present tumor antigens to naive T cells, activating and expanding tumor-specific cytotoxic T lymphocytes (CTLs) [197]