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Additionally, the results of clinical studies of Nrf2 activators in neurodegenerative diseases have been inconsistent, most likely because of genetic differences between individuals (e.g., NLRP3 or NFE2L2), the stage of the disease at intervention, and the differences between the complex pathology of human PD and toxin-based animal models

ZY: Writing original draft

In osteoarthritis models, AOD-9604 treatment resulted in improved cartilage structure and organization

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