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MIRI is strongly associated with ROS-derived damage of tissues both at the ischemic and reperfusion stages observed in 171 , 172

In addition, we have also carried out backreference tracking of the included research and related reviews to retrieve any literature that may be omitted

Many studies have demonstrated the existence of a biased agonism for OR at different signaling events including desensitization, phosphorylation, endocytosis, trafficking, and in vivo effects (see below) (Raehal et al., 2011