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Ciabattini A, Nardini C, Santoro F, Garagnani P, Francesch C, Medaglini D (2018) Vaccination in the elderly: The challenge of immune changes with aging

10.1016/j.jnutbio.2012.08.004 131

In OA studies, direct intra-articular injection of Fer-1 into mouse or rat models significantly reduced the accumulation of lipid peroxidation end-products like MDA and 4-HNE in cartilage tissue, alleviated the degree of ECM degradation, and improved overall joint pathology scores