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Processing of Plasmodium falciparum merozoite surface protein MSP1 activates a spectrin-binding function enabling parasite egress from RBCs

At higher levels of performancewhether in sport, business, or longevitythe difference comes down to something far more technical: Signaling, timing, and restraint

We see a functional iron deficiency when there is reduced heme synthesis or inhibition of heme synthesis either because hemoglobin production is being inhibited or is defective or iron is not being released in sufficient amounts to support hemoglobin production

Notably, shGDH1 cells exhibited extensive cell death at a time point when shCtrl cells remained largely viable (Fig