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Trichostatin A (TSA), derived from Streptomyces, reduces allergic symptoms, nasal inflammation, and IgE levels in AR mice [163]

View Abstract NIH funding of gene therapy trials

Microarray and RNA-sequencing studies have mapped its regulatory effect across approximately 4,000 human genes, including upregulation of VEGF, BDNF, and BMP-2 growth factors central to vascular, neural, and bone remodeling respectively