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There, it significantly mitigated indomethacin-induced leaky gut syndrome via increasing tight junction protein ZO-1 expression, and transepithelial resistance (8), inhibited the mRNA of inflammatory mediators: inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), interferon gamma (IFN), and tumor necrosis factor alpha (TNF-), increased expression of heat shock protein 70 (HSP70) and HSP 90, and antioxidant proteins, such as heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase quinone-1 (NQO-1), glutathione reductase, glutathione peroxidase 2 and glutathione S-transferase pi (GST-) (8)

Activation of target of rapamycin2 (mTORC2) signaling affects PI3K/AKT related apoptosis and protects against cocaine-induced sensorineural hearing loss ( 2.2

This is associated with increased neutrophil influx and IL-8 levels during exacerbations

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