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It is also under a degree of hormonal control and diminishes with low growth hormone levels and increases, at least in normal subjects, with exogenous administration [16]

H., Ke, T

& Popescu, B

Additionally, iron-activated ERK/MAPK pathways may contribute to tau phosphorylation and neuroinflammatory cytokine release, suggesting a potential feedback loop between iron dysregulation, tau pathology, and inflammation (125, 126)