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The prototype drug could not be detected 4 h after administration, and its elimination half-life was less than 30 min

Up until recently, it was believed that cellular senescence, which slows down and stops cell division may be a protective mechanism against cancer

1 H NMR (400 MHz, DMSO- d 6 ) 12.43 (s, 1H), 11.01 (s, 1H), 9.80 (s, 1H), 7.66 (d, J = 7.4 Hz, 1H), 7.57 (dt, J = 14.7, 7.2 Hz, 2H), 7.41 (d, J = 3.7 Hz, 1H), 6.73 (s, 1H), 5.15 (dd, J = 13.3, 5.1 Hz, 1H), 4.30 (dd, J = 57.5, 17.4 Hz, 2H), 4.02 (d, J = 37.5 Hz, 2H), 3.52 (t, J = 14.5 Hz, 2H), 3.12 (t, J = 7.0 Hz, 2H), 2.99 (d, J = 16.8 Hz, 2H), 2.972.81 (m, 3H), 2.72 (dd, J = 23.9, 12.1 Hz, 1H), 2.60 (d, J = 17.2 Hz, 1H), 2.45 (dd, J = 13.1, 8.7 Hz, 1H), 2.03 (d, J = 12.6 Hz, 3H), 1.90 (dd, J = 23.6, 12.4 Hz, 2H), 1.741.56 (m, 4H), 1.45 (d, J = 7.0 Hz, 2H), 1.21 (d, J = 17.7 Hz, 9H)