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Taking into consideration that glial cells outnumber neurons and that an exquisite glial-neuronal interplay takes place in glutamatergic synapses highly enriched in F accumulated structures like the cerebellum and the hippocampus we decided to use two astrocytic models, one with a recognized increase in the exchanger expression (U373-MG cells) and one extremely characterized in terms of its involvement in Glu recycling (BGC) and that is also involved in Glu-dependent gene expression regulation [66]