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Other factors that may cause constipation in a cat include: Stress in the home environment Lack of regular activity and movement Dehydration Eating something inedible (like a foreign object) Not enough fiber in the diet Gastrointestinal disorders (e.g., colorectal mass, strictures) Hormonal or metabolic disorders (e.g., kidney disease or hypothyroidism) Pain when posturing to defecate (due to osteoarthritis or pelvic trauma) Neuromuscular issues (e.g., lesions of the spinal cord) Stress or litterbox aversion When to See the Vet

In addition, the Na + channel inhibitor mexiletine also prevented cold allodynia