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Given that older adults are generally more susceptible to adverse drug reactions and may exhibit heightened PD sensitivity, we adopted a conservative strategy to maintain S-CIT exposures as close as possible to those achieved under monotherapy conditions

To test this hypothesis, we knocked down orthologs of nutrient regulators mTORC1/2 ( let-363) , RRAGA (raga-1 ), AMPK ( aak-2) , FOXO ( daf-16 ), TFEB ( hlh-30 ) and GCN2 ( gcn-2 ) and surveyed SKN-1 activation in amdh-1 mutants

Melanotan II Melanotan II mimics the hormone alpha-melanocyte-stimulating hormone (-MSH), which controls skin pigmentation (28)

Of special note, the former study of Sedley and colleagues 16 also reported a single outlier near zero using the MRS PRESS sequence